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Fructose-Sweetened Beverages Do Not Promote Systemic Inflammation
There is little doubt that increased consumption of fructose-sweetened beverages can be a substantial source of extra calories, thereby potentially promoting weight gain. That said, fructose has also...
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Zafgen Abandons Belanorib Program But Continues Exploring MetAP2 Inhibitor...
Regular readers may recall previous posts on the novel anti-obesity compound belanorib, a MetAP2 inhibitor that showed remarkable weight loss efficacy both in patients with Prader-Willi Syndrome as...
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The Key To Obesity Management Lies In The Science Of Energy Homeostasis
If there is one thing we know for sure about obesity management, it is the sad fact, that no diet, exercise, medication, not even bariatric surgery, will permanently reset the body’s tendency to defend...
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Free Webinar: Assessing Body Fat – Taking Obesity Phenotyping To The Next Level
As readers will be well aware, n terms of health risks, fat is not fat is not fat is not fat. Rather, whether or not body fat affects health depends very much on the type of body fat and its location....
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How The Body Weighs Itself – Evidence For A Bone “Gravitostat”
In my talks, I have often joked about how to best keep weight off – just carry around a backpack that contains the lost pounds to fool the body into thinking the weight is still there. It turns out...
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Molecular Changes During Weight Gain – Everyone Is Different
As one may well imagine, changes in body weight (up or down) can profoundly affect a vast number of hormonal and metabolic pathways. Now, a team of researchers led by Brian Piening and colleagues, in a...
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Can Liraglutide Help Grow New Fat Cells?
The human GLP-1 analogue liraglutide is now approved for the long-term medical treatment of obesity in an ever-increasing number of countries. Its safety and clinical effectiveness is now well...
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The Heterogeneity of Obesity
In the same manner in that there is not one predisposing factor for the development of obesity, the phenotypic clinical presentation of obesity is likewise extraordinarily heterogenous. (This has some...
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Factors Affecting Energy Metabolism: Genetics, Sex, and Aging
Continuing with citations from my article in Obesity Reviews on an aeteological framework for assessing obesity, we now turn to the some of the factors that can affect metabolic rate: Genetics Because...
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The Effects of Obesity on Skeletal Muscle Contractile Function
Skeletal muscle Given that obesity has profound effects on all organ systems, it is not surprising that excess body fat is also associated with a decrease in muscle function. The complex biology of the...
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